| Abstract:Objective To evaluate the clinical efficacy of Jianpi Shugan Fang Granules in the treatment of non-alcoholic fatty liver disease (NAFLD) of liver-qi and spleen-deficiency type, and to explore its influence on intestinal flora. Methods From December 2019 to December 2021, a total of 40 patients with NAFLD of liver-qi and spleen-deficiency syndrome from the Spleen, Department of Gastroenterdogy, Dongfang Hospital of Beijing University of Chinese Medicine were selected and divided into Chinese medicine group and western medicine group by random number table method, 20 cases in each group. The Chinese medicine group was given Jianpi Shugan Fang Granules and Polyene Phosphatidylcholine Capsules simulator. The western medicine group was treated with Polyene Phosphatidylcholine Capsules and Jianpi Shugan Fang Granules Simulator for 12 weeks. Glutamic-pyruvic transaminase (GPT), traditional Chinese medicine syndrome score, liver B-ultrasound, FibroScan controlled attenuation parameter (CAP), safety index, and intestinal flora changes before and after traditional Chinese medicine treatment were detected. Results Three cases fell off, one case was excluded, and 36 cases were included (19 cases in the Chinese medicine group and 17 cases in the western medicine group). After treatment, GPT of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the scores of traditional Chinese medicine syndrome and CAP value in the two groups were lower than before treatment, and those of the traditional Chinese medicine group were lower than those of the western medicine group, with statistical significance (P＜0.05). After treatment, there was no significant difference in the improvement efficiency of liver B-ultrasound between the two groups (P＞0.05). After treatment with Chinese medicine, the proportion of Prevotella and Bacteroides in the stool of the patients increased relatively, while the proportion of Proteobacteria decreased significantly. Conclusion Jianpi Shugan Fang Granules can reduce GPT level, improve traditional Chinese medicine syndromes, reduce liver fat content, and regulate intestinal flora in patients with NALFD with liver-qi and spleen-deficiency, showing good safety. |
