|
二维码（扫一下试试看！） |
| 骨髓来源抑制细胞在创伤后全身炎症反应免疫抑制中作用的研究进展 |
| Study on immunosuppressive effect of bone marrow-derived suppressor cells in trauma induced inflammatory response |
| 收稿日期：2023-07-27 |
| DOI：10.20047/j.issn1673-7210.2024.03.14 |
| 关键词: 髓源抑制细胞 创伤 全身炎症反应 免疫抑制 免疫调节 |
| Key Words: |
| 基金项目:山东省医药卫生科技发展项目（2016WS0709） |
|
| 摘要点击次数: 66 |
| 全文下载次数: 76 |
| 摘要:创伤应激可导致宿主产生过度的全身炎症反应，这些异常是由于对感染的不受控制的反应而发生的，而后期多种机制的作用会导致机体免疫功能处于抑制状态，从而增加脓毒症、多器官衰竭和死亡的风险。免疫抑制机制可调节宿主在清除抗原同时防止继发组织损伤和促进组织修复，而骨髓来源的抑制细胞是介导免疫抑制的主要活性细胞之一，在不同的病理生理时期发挥不同的作用，在创伤早期主要功能是促进组织修复和伤口愈合，而创伤远期可能导致持续性炎症、免疫抑制和分解代谢综合征。本文从多发创伤后免疫炎症反应的不同病理生理阶段，探讨骨髓来源的抑制细胞早期的短暂激活和后期的持续病理激活介导的免疫抑制机制对疾病及转归的积极和消极作用。 |
| Abstract:Traumatic stress can lead to an excessive systemic inflammatory response in the host, which occurs as a result of an uncontrolled response to infection, while later multiple mechanisms can lead to a suppressed immune function, which increases the risk of sepsis, multiple organ failure, and death. The immunosuppressive mechanism can regulate the host to clear antigens while preventing secondary tissue damage and promoting tissue repair. As one of the main active cells mediating immunosuppression, myeloid derived suppressor cells from bone marrow play different roles in different pathophysiological periods, and their main function is to promote tissue repair and wound healing in the early stage of trauma. Long-term trauma may lead to persistent inflammation, immunosuppression, and catabolic syndrome. Based on the different pathophysiological stages of immunoinflammatory response after multiple trauma, this paper explores the positive and negative effects of the immunosuppressive mechanism mediated by the temporary activation of myeloid derived suppressor cells in the early stage and the continuous pathological activation in the later stage on the disease and outcome. |
| 查看全文 HTML 查看/发表评论 下载PDF阅读器 |
