| Abstract:Objective To observe the influence on Sanqi Huogu Pills combined with extracorporeal shock wave (ESW) therapy in patients with early head of femur ischemic necrosis with syndrome of qi stagnation and blood stasis. Methods A total of 72 patients with early head of femur ischemic necrosis with syndrome of qi stagnation and blood stasis admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from April 2021 to October 2022 were selected and divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with ESW, and the observation group was treated with Sanqi Huogu Pills based on the control group. Both groups were treated for four weeks. The visual analogue scale (VAS) score, Harris score of hip joint, and traditional Chinese medicine syndrome score were observed before treatment and two, four weeks after treatment, and the curative effect was evaluated in the two groups. The expression levels of serum interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), and osteoprotegerin (OPG) were compared between the two groups before and after treatment. Results In the control group, four patients took other drugs during treatment, so they were excluded. The clinical effect of the observation group was better than that of the control group (P＜0.05). VAS and traditional Chinese medicine syndrome scores after two and four weeks of treatment were lower than those before treatment, and Harris scores of hip joint were higher than those before treatment, VAS and traditional Chinese medicine syndrome scores after four weeks of treatment were lower than those after two weeks of treatment, and Harris scores of hip joint were higher than after two weeks of treatment (P＜0.05). After two and four weeks of treatment, the Harris scores of hip joint of the observation group were higher than those of the control group, and the traditional Chinese medicine syndrome scores were lower than those of the control group (P＜0.05). After four weeks of treatment, VAS scores of observation group was lower than those of control group (P＜0.05). After four weeks of treatment, serum IL-1β, IL-6, and TNF-α levels in two groups were lower than those before treatment, serum OPG level was higher than those before treatment, and serum IL-1β, IL-6 and TNF-α levels in observation group were lower than those in control group, and serum OPG level was higher than that in control group (P＜0.05). Conclusion Sanqi Huogu Pills combined with ESW has a good effect on improving the symptoms of patients with early ischemic necrosis of head of femur with syndrome of qi stagnation and blood stasis, which is suitable for clinical application. |
