| 何星伯,赵萍,郭滨,蒋文君,吴建峰.抑制蛋白在常见有遗传倾向疾病中的研究进展[J].中国医药导报,2024,21(1):47-50 |
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| 抑制蛋白在常见有遗传倾向疾病中的研究进展 |
| Research progress on arrestin in common genetic and tendentious diseases |
| 收稿日期：2023-06-28 |
| DOI：10.20047/j.issn1673-7210.2024.01.09 |
| 关键词: 抑制蛋白 阻遏蛋白 遗传性疾病 眼科疾病 心血管疾病 综述 |
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| 基金项目:国家自然科学基金青年科学基金资助项目（82205198）；山东省自然科学基金面上项目（ZR2020MH393）；中国博士后科学基金面上项目（2022M711984、2020 M672127） |
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| 摘要:抑制蛋白又称阻遏蛋白，是哺乳动物中细胞信号转导的调节因子，与许多疾病的发生密切相关。抑制蛋白可通过调控β-肾上腺素能受体和血管紧张素Ⅱ受体影响心血管舒张功能改善心血管疾病；上调视网膜色素上皮中的成纤维细胞维持视网膜稳态，以及在感光细胞中的增多对视网膜具有保护作用；降低多巴胺表达改善精神类疾病；参与小胶质细胞自噬过程改善神经系统疾病；增加肝细胞、脂肪细胞、β细胞的质量及增殖率改善胰岛素信号传导治疗代谢性相关疾病。本文综述抑制蛋白对以上具有遗传倾向常见疾病的发病机制及治疗等，旨在为临床治疗提供新的思路。 |
| Abstract:Arrestin also known as repressor protein, which is regulatory factors in cellular signal transduction in mammals and is closely related to the occurrence of many diseases. Arrestin can be regulated by β-adrenergic receptors and angiotensin Ⅱ receptors affect cardiovascular diastolic function and improve cardiovascular disease; upregulation of fibroblasts in retinal pigment epithelium to maintain retinal homeostasis, as well as an increase in photoreceptor cells, have a protective effect on the retina; reducing dopamine expression and improving psychiatric disorders; participate in the autophagy process of microglia to improve neurological diseases; increase liver cells, adipocytes, β cells quality and proliferation rate in order to improve insulin signaling transduction in the treatment of metabolic related diseases. This article reviews the pathogenesis and treatment of common genetic and tendentious diseases by arrestin, aiming to provide new ideas for clinical treatment. |
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