| 金曼诗,马铁明,李记泉,陈语嫣,谢正伦.P物质在皮肤源性瘙痒发病机制中的研究进展[J].中国医药导报,2024,21(2):49-52 |
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| P物质在皮肤源性瘙痒发病机制中的研究进展 |
| Research progress of substance P in the pathogenesis of skin derived itching |
| 收稿日期：2023-04-25 |
| DOI：10.20047/j.issn1673-7210.2024.02.09 |
| 关键词: P物质 皮肤源性瘙痒 肥大细胞 研究进展 |
| Key Words: |
| 基金项目:国家自然科学基金青年科学基金资助项目（82205253）；中国博士后科学基金面上资助项目（2021M 693850）；辽宁省自然科学基金博士启动计划项目（2022-BS- 199）；辽宁省“兴辽英才计划”项目（XLYC1902004） |
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| 摘要:皮肤源性瘙痒的发生机制较为复杂且目前尚未完全阐明。P物质是一种由皮肤感觉神经元释放的神经肽，是介导瘙痒的重要物质基础。该物质可以通过P物质/神经激肽1受体系统、P物质/G蛋白偶联受体X2系统激活肥大细胞，从而引发瘙痒。研究表明，降低P物质在血浆及皮肤组织中的表达能够缓解瘙痒症状。本文对P物质与皮肤源性瘙痒之间的关系及其在发病机制中的作用进行论述，以期为今后临床应用及基础研究提供思路。 |
| Abstract:The mechanism of skin derived itching is complex and currently not fully elucidated. Substance P, a neuropeptide released by sensory neuron in the skin, is an important material basis for mediate itching. This substance can can be through the substance P/neurokinin-1 receptor system and substance P/mas-related G-protein coupled receptor X2 system activation of mast cells, causing itching. Research has shown that reducing the expression of substance P in plasma and skin tissue can alleviate itching symptoms. This article discusses the relationship between substance P and skin derived itching and its role in the pathogenesis, in order to provide ideas for clinical applications and basic research in the future. |
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