| 钱恩惠,蒋文泽,侯雅婷,鲁科达.中医药调节硫酸吲哚酚相关机体损伤干预慢性肾脏病及其并发症的研究进展[J].中国医药导报,2024,21(2):57-61 |
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| 中医药调节硫酸吲哚酚相关机体损伤干预慢性肾脏病及其并发症的研究进展 |
| Research progress of Chinese medicine regulating indoxyl sulfate related body injury in the intervention of chronic kidney disease and its complications |
| 收稿日期：2023-07-18 |
| DOI：10.20047/j.issn1673-7210.2024.02.11 |
| 关键词: 中医药 慢性肾脏病 硫酸吲哚酚 并发症 研究进展 |
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| 基金项目:浙江省中医药现代化专项项目（2021ZX007）；浙江省中医药重点研究项目（2020ZZ008） |
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| 摘要:近年来，肠源性尿毒症毒素硫酸吲哚酚被发现与慢性肾脏病及其并发症的发生和发展密切相关，而以中医药为干预对象来调节硫酸吲哚酚引起的机体损伤的临床试验及基础试验也逐渐丰满，一些可能机制的探索也初有成效，主要通过调整肠道菌群比例、降低硫酸吲哚酚前体合成及阻止芳香烃受体途径启动来干预慢性肾脏病及并发症的发生和发展，现系统回顾中医药以硫酸吲哚酚为治疗靶点的临床证据及机制探索，以期为中医药在该领域的进一步发展提供更多循证依据和思路参考。 |
| Abstract:In recent years, indoxyl sulfate, an enteric-borne uremic toxin, has been found to be closely related to the occurrence and development of chronic kidney disease and its complications. Clinical trials and basic trials on the regulation of body damage caused by indoxyl sulfate with traditional Chinese medicine as the intervention object have been gradually completed, and the exploration of some possible mechanisms has also achieved initial results. It mainly intervenes in the occurrence and development of chronic kidney disease and complications by adjusting the proportion of intestinal flora, reducing the synthesis of the precursor of indoxyl sulfate and preventing the initiation of the aromatic hydrocarbon receptor pathway. This paper systematically reviews the clinical evidence and mechanism exploration of indoxyl sulfate as the therapeutic target of traditional Chinese medicine, in order to provide more evidence-based basis and train of thought reference for the further development of traditional Chinese medicine in this field. |
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