| 杜慧玲,汪杰,熊恩来,张斌.红细胞体积分布宽度对慢性重度心力衰竭患者预后的影响[J].中国医药导报,2024,21(2):85-89 |
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| 红细胞体积分布宽度对慢性重度心力衰竭患者预后的影响 |
| Effect of red cell volume distribution width on prognosis of patients with chronic severe heart failure |
| 收稿日期：2023-06-06 |
| DOI：10.20047/j.issn1673-7210.2024.02.17 |
| 关键词: 红细胞体积分布宽度 心力衰竭 预后 临床研究 |
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| 基金项目:安徽省铜陵市卫生健康委员会科研基金项目（卫科研〔2021〕7号） |
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| 摘要:目的 探讨红细胞体积分布宽度（RDW）对慢性重度心力衰竭患者预后的影响。 方法 选取2021年1月至12月在安徽省铜陵市人民医院住院的慢性重度心力衰竭患者（心功能Ⅲ～Ⅳ级）101例，根据入院时RDW水平将其分为RDW升高组（40例）及RDW正常组（61例），比较两组临床指标。对两组出院后进行1年的随访，比较两组的生存率和未再住院率，通过单变量及多变量回归分析评价影响因素。 结果 RDW升高组住院天数、糖尿病患病率高于RDW正常组，血红蛋白和肌酐清除率低于RDW正常组，差异有统计学意义（P＜0.05）。随访结束，两组生存率比较，差异无统计学意义（P＞0.05），RDW升高组未再住院率低于RDW正常组，差异有统计意义（P＜0.05）。Cox比例风险模型分析结果显示，肌酐清除率、左室射血分数、脑利尿钠肽、RDW是慢性重度心力衰竭患者再住院的影响因素（P＜0.05），其中肌酐清除率、左室射血分数、RDW是独立影响因素（P＜0.05）。 结论 RDW是慢性重度心力衰竭的预后的影响因素，可作为基层医院心力衰竭诊治的重要的指标之一。 |
| Abstract:Objective To investigate the effect of red blood cell volume distribution width (RDW) on prognosis of patients with chronic severe heart failure. Methods A total of 101 patients with chronic severe heart failure (grade Ⅲ to Ⅳ) admitted to the Tongling People’s Hospital, Anhui Province from January to December 2021 were selected and divided into elevated RDW group (40 cases) and normal RDW group (61 cases) according to the RDW level at admission. The clinical indexes of the two groups were compared. The two groups were followed up for one year after discharge, the survival and non-readmission rates of the two groups were compared, and the influencing factors were evaluated by univariate and multivariate regression analysis. Results The length of hospital stays and prevalence of diabetes in elevated RDW group were higher than those in normal RDW group, and the hemoglobin and creatinine clearance were lower than those in normal RDW group, the differences were statistically significant (P＜0.05). At the end of follow-up, there was no significant difference in survival rate between the two groups (P＞0.05), and the non-readmission rate in the elevated RDW group was lower than that in the normal RDW group, the difference was statistically significant (P＜0.05). The results of Cox proportional risk model analysis showed that creatinine clearance, left ventricular ejection fraction, brain natriuretic peptide, and RDW were the influencing factors of re-hospitalization in patients with chronic severe heart failure (P＜0.05), and creatinine clearance, left ventricular ejection fraction, and RDW were the independent influencing factors (P＜0.05). Conclusion RDW is a prognostic factor of chronic and severe heart failure, and can be used as one of the important indicators in the diagnosis and treatment of heart failure in primary hospitals. |
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