| 马春然,白华,王欢,杨勇昆.骨肿瘤化疗患者的癌因性疲乏现状及其影响因素[J].中国医药导报,2024,21(2):120-123 |
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| 骨肿瘤化疗患者的癌因性疲乏现状及其影响因素 |
| Status and influencing factors of cancer- related fatigue in patients with bone tumor undergoing chemotherapy |
| 收稿日期：2023-04-06 |
| DOI：10.20047/j.issn1673-7210.2024.02.25 |
| 关键词: 骨肿瘤 化疗 癌因性疲乏 社会支持 自我效能 影响因素 |
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| 基金项目:北京市医院管理中心青年人才培养“青苗”计划项目（QML20200403） |
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| 摘要:目的 探讨骨肿瘤化疗患者的癌因性疲乏（CRF）现状及其影响因素。 方法 选取2020年2月至2021年1月于首都医科大学附属北京积水潭医院接受化疗的骨肿瘤患者100例，患者进行修订Piper疲乏量表中文版（RPFS-CV）、社会支持评定量表（SSRS）、一般自我效能感量表（GSES）测评。患者根据是否存在CRF分为CRF组（RPFS-CV评分＞3分，26例）和非CRF组（RPFS-CV评分≤3分，74例）。比较两组临床资料，采用多因素logistic回归分析确定CRF的影响因素。 结果 本研究中100例骨肿瘤化疗患者的RPFS-CV总分为（4.54±1.02）分。CRF组Ennecking分期为Ⅲ及Ⅳ期占比、病程、化疗次数高于非CRF组，SSRS、GSES评分低于非CRF组，差异有统计学意义（P＜0.05）。回归分析显示，Ennecking分期（OR=1.485，95%CI：1.102～2.001）、化疗次数（OR=2.307，95%CI：1.387～3.837）、SSRS评分（OR=0.319，95%CI：0.141～0.722）、GSES评分（OR=0.512，95%CI：0.299～0.877）是CRF的影响因素（P＜0.05）。 结论 社会支持及自我效能会影响骨肿瘤化疗患者CRF，从患者社会支持及自我效能方面进行积极干预有利于减轻患者CRF。 |
| Abstract:Objective To investigate the status and influencing factors of cancer- related fatigue (CRF) in patients with bone tumor undergoing chemotherapy. Methods A total of 100 patients with bone tumor received chemotherapy in Beijing Jishuitan Hospital, Capital Medical University from February 2020 to January 2021 were selected, and assessed by revised Piper fatigue scale-Chinese version (RPFS-CV), social support rating scale (SSRS), and general self-efficacy scale (GSES). Patients were divided into CRF group (RPFS-CV score＞three points, 26 cases) and non-CRF group (RPFS-CV score ≤three points, 74 cases) according to the presence or absence of CRF. The clinical data of the two groups were compared, and the influencing factors of CRF were determined by multivariate logistic regression analysis. Results In this study, the total score of RPFS-CV in 100 patients with bone tumor chemotherapy was (4.54±1.02) points. The proportion of Ennecking stages Ⅲ and Ⅳ, duration of disease, and frequency of chemotherapy in CRF group were higher than those in non-CRF group, and SSRS and GSES scores were lower than those in non-CRF group, the differences were statistically significant (P＜0.05). Regression analysis showed that Ennecking stage (OR=1.485, 95%CI: 1.102-2.001), chemotherapy frequency (OR=2.307, 95%CI: 1.387-3.837), SSRS score (OR=0.319, 95%CI: 0.141-0.722), and GSES score (OR=0.512, 95%CI: 0.299-0.877) were the influencing factors of CRF (P＜0.05). Conclusion Social support and self-efficacy can affect CRF in patients with bone tumor chemotherapy. Active intervention in social support and self-efficacy is conducive to reducing CRF in patients. |
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