| 马明男,朱霞,李慧珍,赵雨恒,黄炜瑜,马天仲.非预期卵巢低反应患者的影响因素及个体化治疗的研究进展[J].中国医药导报,2024,21(3):60-63 |
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| 非预期卵巢低反应患者的影响因素及个体化治疗的研究进展 |
| Research progress on influencing factors of patients with unexpected poor ovarian response and individualized treatment |
| 收稿日期：2023-06-08 |
| DOI：10.20047/j.issn1673-7210.2024.03.11 |
| 关键词: 波塞冬标准 非预期卵巢低反应 胚胎质量 个体化治疗 |
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| 基金项目:广东省基础与应用基础研究自然科学基金项目（2022A1515010849） |
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| 摘要:目前针对非预期卵巢低反应（POR）的治疗策略侧重于获取更多的卵母细胞，而波塞冬标准的提出至少获取1个可移植的整倍体胚胎，成为辅助生殖技术成功的新指标，因此将仅有的卵母细胞培育成优质胚胎是此类患者治疗的重要方面。本文重点阐述影响非预期POR的相关因素及其获取优质胚胎个体化治疗相关的7个措施：扳机日卵泡大小、双扳机方案、人工卵母细胞激活、囊胚移植、植入前非整倍体检测、时差成像、生物工程技术的应用。 |
| Abstract:Current treatment strategies for unexpected poor ovarian response (POR) focus on obtaining more oocytes, and the POSEIDON standard proposes to obtain at least one transplantable euploid embryo, it has become a new indicator of the success of assisted reproductive technology, so growing the only oocytes into high-quality embryos is an important aspect of the treatment of such patients. This paper focuses on the related factors affecting unexpected POR and seven measures related to obtaining high-quality embryo individualized treatment: trigger day follicle size, double trigger protocol, artificial oocyte activation, blastocyst transfer, preimplantation genetic testing for aneuploidy, time-lapse imaging, application of bioengineering techniques. |
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