| 郭晓莹,陈哲.急性白血病化疗患者的癌因性疲乏现状及与生活质量的相关性分析[J].中国医药导报,2024,21(3):90-92 |
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| 急性白血病化疗患者的癌因性疲乏现状及与生活质量的相关性分析 |
| Status of cancer-related fatigue and its correlation with quality of life in patients with acute leukemia undergoing chemotherapy |
| 收稿日期：2023-02-24 |
| DOI：10.20047/j.issn1673-7210.2024.03.18 |
| 关键词: 急性髓系白血病 化疗 癌因性疲乏 生活质量 相关性 |
| Key Words: |
| 基金项目:河北省医学科学研究课题计划项目（20210427） |
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| 摘要:目的 探讨急性髓系白血病（AML）患者的癌因性疲乏（CRF）及与生活质量的相关性。 方法 选取2019年9月至2022年9月于河北北方学院附属第一医院就诊的AML患者106例，调查患者一般情况，采用Piper疲乏量表（PFS）、白血病特异性生活质量评估量表（FACT-Leu）评估患者CRF与生活质量，并分析相关性。比较不同临床特征患者的FACT-Leu总分并进行多元线性回归分析。 结果 106例患者的PFS评分为（3.87±0.66）分，FACT-Leu总分为（104.60±7.94）分，二者呈负相关（r=-0.296，P＜0.05）。不同文化程度、病程、化疗疗程、PFS评分患者的FACT-Leu评分比较，差异有统计学意义（P＜0.05）。多元线性回归分析显示，文化程度与FACT-Leu总分呈正相关趋势（B＞0，P＜0.05）；化疗疗程和PFS评分（与FACT-Leu总分呈负相关趋势（B＜0，P＜0.05）。 结论 CRF与AML化疗患者的生活质量有明显相关性，针对疲乏情况进行干预有利于提高生活质量。 |
| Abstract:Objective To investigate the relationship between cancer-related fatigue (CRF) and quality of life in patients with acute myeloid leukemia (AML). Methods A total of 106 AML patients admitted to the First Affiliated Hospital of Hebei North University from September 2019 to September 2022 were selected to investigate the general conditions of the patients. Piper fatigue scale (PFS) and functional cancer therapy-leukemia (FACT-Leu) were used to evaluate the CRF and quality of life of the patients, and the correlation was analyzed. The total FACT-Leu scores of patients with different clinical features were compared and multiple linear regression analysis was performed. Results The PFS score and FACT-Leu score of 106 patients were (3.87±0.66) points and (104.60±7.94) points, and the two were negatively correlated (r=-0.296, P＜0.05). There were significant differences in FACT-Leu scores among patients with different education level, course of disease, chemotherapy course, and PFS score (P＜0.05). Multiple linear regression analysis showed that education level was positively correlated with the total score of FACT-Leu (B＞0, P＜0.05), chemotherapy duration and PFS score were negatively correlated with FACT-Leu score (B＜0, P＜0.05). Conclusion There is a significant correlation between CRF and the quality of life of AML patients treated with chemotherapy, and intervention for fatigue is beneficial to improve the quality of life. |
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