| 鲍明珠,董艳,赵丹玲,张松英.雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性[J].中国医药导报,2024,21(3):122-126 |
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| 雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性 |
| Effect and safety of estrogen combined with Dydrogesterone in the treatment of ovulatory dysfunction abnormal uterine bleeding during gestational age |
| 收稿日期：2023-05-17 |
| DOI：10.20047/j.issn1673-7210.2024.03.25 |
| 关键词: 孕龄期 排卵障碍性异常子宫出血 雌激素 地屈孕酮 疗效 |
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| 基金项目:江苏省妇幼健康科研项目（F201903） |
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| 摘要:目的 研究雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性。 方法 选取2020年2月至2021年2月徐州医科大学附属沭阳医院妇产科孕龄期排卵障碍性异常子宫出血患者192例，按照随机数字表法分为单药组、联合组，各96例。单药组采用地屈孕酮治疗，联合组采用雌激素联合地屈孕酮治疗，两组均治疗3个月。比较两组临床疗效、止血情况；比较两组治疗前后月经周期、月经持续时间、子宫内膜厚度及性激素水平[卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）]；记录不良反应发生情况。 结果 联合组临床疗效优于单药组（P＜0.05）。联合组出血控制时间、完全止血时间短于单药组（P＜0.05）。治疗后，两组月经周期、月经持续时间短于治疗前，且联合组短于单药组（P＜0.05）；两组子宫内膜厚度、FSH、LH、E2水平低于治疗前，且联合组低于对照组（P＜0.05）。两组不良反应总发生率比较，差异无统计学意义（P＞0.05）。 结论 雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血效果明显，能缓解止血情况，调节月经周期、月经持续时间及子宫内膜厚度，降低性激素水平，安全性高。 |
| Abstract:Objective To study the effect and safety of estrogen combined with Dydrogesterone in the treatment of ovulatory dysfunction abnormal uterine bleeding during gestational age. Methods A total of 192 patients with ovulatory dysfunction abnormal uterine bleeding during gestational age of the Affiliated Shuyang Hospital of Xuzhou Medical University from February 2020 to February 2021 were selected, and they were divided into single drug group and combined group according to random number table method, with 96 cases in each group. The single drug group was treated with Dydrogesterone, and the combined group was treated with estrogen combined with Dydrogesterone, both groups were treated for three months. The clinical effect and hemostasis of two groups were compared; the menstrual cycle, menstrual duration, endometrial thickness, and sex hormone levels (follicle stimulating hormone [FSH], luteinizing hormone [LH], estradiol [E2]) before and after treatment were compared between two groups; and the occurrence of adverse reactions were recorded. Results The clinical efficacy in combined group was better than that in single drug group (P＜0.05). The bleeding control time and complete hemostasis time in combined group were shorter than those in single drug group (P＜0.05). After treatment, the menstrual cycle, menstrual duration were shorter than those before treatment, and the combined group was shorter than single drug group (P＜0.05); the endometrial thickness and the levels of FSH, LH, and E2 in two groups were lower than those before treatment, and the combined group was lower than single drug group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Estrogen combined with Dydrogesterone is effective in the treatment of ovulatory dysfunction abnormal uterine bleeding during gestational age. It can improve hemostasis, regulate menstrual cycle, menstrual duration, and endometrial thickness, reduce the level of sex hormones, and has high safety. |
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