| 吴涵,王秀.羟氯喹在子痫前期防治应用潜能的研究进展[J].中国医药导报,2024,21(4):62-65 |
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| 羟氯喹在子痫前期防治应用潜能的研究进展 |
| Research progress of potential application of hydroxychloroquine in prevention and treatment of preeclampsia |
| 收稿日期： 修订日期：2023-07-10 |
| DOI：10.20047/j.issn1673-7210.2024.04.14 |
| 关键词: 羟氯喹 子痫前期 Toll样受体 氧化应激 |
| Key Words: |
| 基金项目:陕西省科技攻关基金资助项目（2018SF-210） |
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| 摘要:羟氯喹具有抗炎、免疫调节、抗血栓、抗氧化等多种药理作用，研究证明羟氯喹对系统性红斑狼疮的妊娠妇女有诸多益处，能够改善妊娠结局、降低子痫前期发生率等。子痫前期是一种复杂的妊娠特发性疾病，对于围生期母儿有严重危害，发病机制尚不明确，但目前认为子痫前期的发生、发展与全身炎症反应、氧化应激及内皮功能障碍等有密切关系。考虑羟氯喹的多种药理作用，本文从羟氯喹抗炎、抗氧化、改善内皮功能及抑制自噬等4个方面作一综述，探讨羟氯喹可能在子痫前期预防和治疗方面发挥作用的相关机制。 |
| Abstract:Hydroxychloroquine has anti-inflammatory, immunomodulatory, antithrombotic, antioxidant, and other pharmacological effects. Studies have proved that hydroxychloroquine has many benefits for pregnant women with systemic lupus erythematosus, which can improve pregnancy outcomes and reduce the incidence of preeclampsia. Preeclampsia is a complex idiopathic disease of pregnancy, which has serious harm to the perinatal mother and child. The pathogenesis is still unclear, but it is believed that the occurrence and development of preeclampsia are closely related to systemic inflammatory response, oxidative stress, and endothelial dysfunction. Therefore, considering the various pharmacological effects of hydroxychloroquine, this article reviews four aspects of hydroxychloroquine: anti-inflammatory, antioxidant, improvement of endothelial function and inhibition of autophagy, and discusses the relevant mechanisms of hydroxy- chloroquine’s possible role in the prevention and treatment of preeclampsia. |
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