| 周玥莹,曲义坤.过表达趋化因子CXCL1在胃癌中的作用及研究进展[J].中国医药导报,2024,21(5):49-52 |
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| 过表达趋化因子CXCL1在胃癌中的作用及研究进展 |
| Role and research progress of overexpressing chemokine CXCL1 in gastric cancer |
| 收稿日期： 修订日期：2023-07-17 |
| DOI：10.20047/j.issn1673-7210.2024.05.12 |
| 关键词: 趋化因子生长调节基因1 胃癌 转移 侵袭 |
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| 基金项目:黑龙江省自然科学基金资助项目（LH2021H109） |
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| 摘要:胃癌是全球第五大常见癌症和第四大癌症相关死亡原因。胃癌的致病因素多样化，随着人平均寿命的增长，胃癌的发病率也呈上升趋势。因此，早期诊断出胃癌患者对改善患者预后有很大帮助。近年来，胃癌的传统治疗手段逐渐进入瓶颈期，需要开发出新的治疗措施。胃癌研究的一个领域是胃癌细胞和免疫细胞之间的相互作用，其中趋化因子起着至关重要的作用。随着趋化因子生长调节基因1（CXCL1）与胃癌关系的日益明晰，趋化因子CXCL1有望成为胃癌治疗的一个有前途的靶点。本文就近年来过表达趋化因子CXCL1在胃癌中的研究进展进行简要综述。 |
| Abstract:Stomach cancer is the fifth most common cancer and the fourth leading cause of cancer-related death worldwide. The pathogenic factors of gastric cancer are diversified. With the increase of average life span, the incidence of gastric cancer is also on the rise. Therefore, early diagnosis of gastric cancer patients is of great help to improve the prognosis of patients. In recent years, the traditional treatment of gastric cancer has gradually entered a bottleneck period, and new therapeutic measures need to be developed. One area of gastric cancer research is the interaction between gastric cancer cells and immune cells, in which chemokines play a crucial role. With the increasingly clear relationship between chemokine growth regulatory gene 1 (CXCL1) and gastric cancer, CXCL1 is expected to become a promising target for the treatment of gastric cancer. In this review, the research progress of overexpressing chemokine CXCL1 in gastric cancer in recent years was reviewed. |
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