| 封玉宁,马思田,范小璇,林隆杰,赵晓平.脑出血相关影响因素分析[J].中国医药导报,2024,21(5):91-94 |
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| 脑出血相关影响因素分析 |
| Analysis of risk factors related to intracerebral hemorrhage |
| 收稿日期： 修订日期：2023-07-31 |
| DOI：10.20047/j.issn1673-7210.2024.05.22 |
| 关键词: 脑出血 危险因素 收缩压 同型半胱氨酸 低密度脂蛋白胆固醇 |
| Key Words: |
| 基金项目:国家自然科学基金资助项目（81873288）；陕西省重点研发计划项目（2019ZDLSF04-06-01）；陕西省中西医结合临床协作创新项目（2020-ZXY007） |
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| 摘要:目的 分析脑出血发生的相关影响因素。 方法 2021年11月至2022年12月陕西中医药大学第一临床医学院共纳入71例脑出血患者为病例组，收集所有受试者的一般情况、既往史、生活嗜好、家族史、入院血压、随机血糖及生化指标，根据样本特征选取同期35例非脑出血人群配对为对照组，采用logistic回归分析筛选出与脑出血发病相关的影响因素。 结果 病例组入院时收缩压、舒张压、入院随机血糖、同型半胱氨酸（Hcy）高于对照组，胱氨酸蛋白酶抑制剂C（CysC）、总胆固醇、低密度脂蛋白胆固醇（LDL-C）低于对照组，差异有统计学意义（P＜0.05）。logistic回归分析显示，入院时收缩压（OR=0.884，P=0.001）、LDL-C（OR=21.521，P=0.007）、Hcy（OR=0.863，P=0.007）为脑出血发病的独立影响因素。 结论 脑出血的发生是多因素共同作用的结果，入院时收缩压升高、Hcy水平增高可能会增加其风险，LDL-C水平增高可能会降低其风险，临床治疗中应对这些指标异常的患者加强监测。 |
| Abstract:Objective To explore the related risk factors of intracerebral hemorrhage. Methods A total of 71 patients with were included from November 2021 to December 2022 in the First Clinical Medical College of Shaanxi University of Chinese Medicine were selected as patient group. The general condition, past history, lifestyle, family history, admission blood pressure, random blood glucose, and biochemical indexes of all subjects were collected. Additionally, 35 non-cerebral hemorrhage populations were selected for the control group during the same period based on the sample characteristics. Logistic regression analysis was used to screen out the independent risk factors associated with the occurrence of intracerebral hemorrhage. Results Systolic blood pressure, diastolic blood pressure, random blood glucose, and homocysteine (Hcy) on admission in patient group were higher than those in control group, and cystine protease inhibitor C (CysC), total cholesterol, and low density lipoprotein-cholesterol (LDL-C) were lower than those in control group, and the differences were statistically significant (P＜0.05). Logistic-regression analysis showed that, the systolic blood pressure(OR=0.884, P=0.001), LDL-C(OR=21.521, P=0.007), and Hcy(OR=0.863，P=0.007) on admission were independent influencing factors associated with the occurrence of intracerebral hemorrhage. Conclusion The occurrence of intracerebral hemorrage is the result of combination of multiple factors. The increased systolic blood pressure, the increased Hcy on admission may increase its risk, while the increased LDL-C may reduce its risk. In clinical care, more intensive monitoring of the patients with abnormalities in these indicators under surveillance is required. |
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