| 张春,李素花,施晓莺.垂体后叶素联合缩宫素在子宫肌瘤剔除术中的应用效果[J].中国医药导报,2024,21(5):115-118 |
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| 垂体后叶素联合缩宫素在子宫肌瘤剔除术中的应用效果 |
| Application effect of Pituitrin combined with Oxytocin in uterine myomectomy |
| 收稿日期： 修订日期：2023-07-19 |
| DOI：10.20047/j.issn1673-7210.2024.05.27 |
| 关键词: 子宫肌层 垂体后叶素 缩宫素 子宫肌瘤剔除术 |
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| 基金项目:安徽省科技攻关项目（2204h08020246） |
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| 摘要:目的 探究垂体后叶素联合缩宫素在子宫肌瘤剔除术中的应用效果。 方法 选取2019年12月至2022年10月安徽省阜阳市肿瘤医院妇产科拟行子宫肌瘤剔除术的82例子宫肌瘤患者，按照随机数字表法将其分为两组，每组41例。对照组术中注射缩宫素，观察组在对照组的基础上注射垂体后叶素。比较两组术前（T0）、注射后15 min（T1）、注射后1 h（T2）的血压、心率及血氧饱和度（SpO2）水平；比较两组手术情况和不良反应发生情况。 结果 整体分析：两组收缩压时间、组间、交互作用比较，差异有统计学意义（P＜0.05）；组内比较：两组T1时收缩压高于T0时，T2时低于T1时（P＜0.05）；组间比较：观察组T1时收缩压高于对照组（P＜0.05）。两组舒张压时间、组间、交互作用比较，差异无统计学意义（P＞0.05）。整体分析：两组心率时间、组间、交互作用比较，差异有统计学意义（P＜0.05）；组内比较：两组T1时心率高于T0时，T2时低于T1时（P＜0.05）；组间比较：观察组T1时心率高于对照组（P＜0.05）。两组SpO2时间、组间、交互作用比较，差异无统计学意义（P＞0.05）。观察组手术时间短于对照组，术中出血量少于对照组（P＜0.05）。两组心血管不良反应总发生率比较，差异无统计学意义（P＞0.05）。观察组术后并发症总发生率低于对照组（P＜0.05）。结论 子宫肌层注射垂体后叶素联合缩宫素能够缩短手术时间及住院时间，减少术中出血量及并发症的发生。 |
| Abstract:Objective To explore the application effect of Pituitrin combined with Oxytocin in uterine myomectomy. Methods A total of 82 patients with uterine fibroids who were to undergo uterine myomectomy in the Department of Obstetrics and Gynecology, Fuyang Cancer Hospital of Anhui Province from December 2019 to October 2022 were selected, and they were divided into two groups according to the random number table method, with 41 cases in each group. The control group was injected with Oxytocin during operation, and observation group was injected with Pituitrin on the basis of control group. The levels of blood pressure, heart rate, and blood oxygen saturation (SpO2) before operation (T0), 15 min after injection (T1), and 1 h after injection (T2) of two groups were compared; and the operation status and adverse reactions of two groups were compared. Results Overall analysis: there were statistically significant insystolic blood pressure time, intergroup, and interaction between two groups (P＜0.05); intra-group comparison: systolic blood pressure at T1 was higher than that at T0, and when T2 was lower than that at T1 (P＜0.05); comparison between groups: systolic blood pressure at T1 of observation group was higher than that of control group (P＜0.05); there was no significant difference in diastolic blood pressure time, inter-group, and interaction between two groups (P＞0.05). Overall analysis: there were statistically significant differences in heart rate time, intergroup, and interaction between two groups (P＜0.05); intra-group comparison: heart rate at T1 was higher than that at T0, when T2 was lower than that at T1 (P＜0.05); comparison between groups: heart rate at T1 of observation group was higher than that of control group (P＜0.05). There was no significant difference in SpO2 time, inter-group, and interaction between two groups (P＞0.05). The operation time of observation group was shorter than that of control group, and the amount of blood loss during operation was lower than that of control group (P＜0.05). There was no significant difference in the total incidence of cardiovascular adverse reactions between two groups (P＞0.05). The total incidence of postoperative complications in observation group was lower than that in control group (P＜0.05). Conclusion Myometrium injection of Pituitrin combined with Oxytocin can shorten the duration of operation and hospital stay, reduce the amount of intraoperative blood loss and complications. |
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