| 贲如银,贲如琴,季进锋,黄潇潇,黄浩,范玲玲.外周血辅助性T细胞17细胞水平、单核细胞/淋巴细胞比值联合预测结直肠癌患者预后的价值分析[J].中国医药导报,2024,21(5):119-122 |
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| 外周血辅助性T细胞17细胞水平、单核细胞/淋巴细胞比值联合预测结直肠癌患者预后的价值分析 |
| Analyse of prognostic value of peripheral blood helper T cell 17 level and monocyte/lymphocyte ratio in patients with colorectal cancer |
| 收稿日期： 修订日期：2023-07-20 |
| DOI：10.20047/j.issn1673-7210.2024.05.28 |
| 关键词: 结直肠癌 预后评估 辅助性T细胞17 单核细胞/淋巴细胞比值 |
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| 基金项目:江苏省自然科学基金项目（BK20191208） |
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| 摘要:目的 探究外周血辅助性T细胞17（Th17）水平、单核细胞/淋巴细胞比值（MLR）联合预测结直肠癌患者预后的价值。 方法 选取江苏省南通市肿瘤医院在2015年1月至2017年12月收治的结直肠癌患者89例（至少完成5年随访），根据预后情况将其分为预后良好组（58例）与预后不良组（31例），收集两组临床相关资料及外周血Th17、MLR。分析结直肠癌患者预后的影响因素，采用受试者操作特征（ROC）曲线评估Th17、MLR及联合检测对患者预后的预测价值。 结果 预后不良组临床分期为Ⅲ～Ⅳ期占比、低分化占比及外周血Th17、MLR均高于预后良好组，差异有统计学意义（P＜0.05）。多因素分析显示，临床分期（OR=1.985，95%CI：1.167～3.376）、Th17水平（OR=2.126，95%CI：1.310～3.449）、MLR（OR=2.353，95%CI：1.276～4.337）是影响结直肠患者预后的独立危险因素（P＜0.05）。ROC曲线分析显示，Th17、MLR单独及二者联合预测患者预后的曲线下面积分别为0.732、0.746、0.939。 结论 外周血Th17、MLR是影响结直肠癌患者预后的独立危险因素，且二者联合检测可有效预测患者预后。 |
| Abstract:Objective To explore the prognostic value of peripheral blood helper T cell 17 (Th17) level and monocyte/ lymphocyte ratio (MLR) in patients with colorectal cancer. Methods A total of 89 patients with colorectal cancer admitted to Nantong Cancer Hospital in Jiangsu Province from January 2015 to December 2017 (with at least five years of follow-up) were selected and divided into good prognosis group (58 cases) and poor prognosis group (31 cases) according to the prognosis. Relevant clinical data, and peripheral blood Th17, MLR of the two groups were collected. The influencing of prognostio factors of colorectal cancer patients were analyzed, and the predictive value of Th17, MLR, and combined detection was evaluated by receiver operating characteristic (ROC) curve. Results The proportion of clinical stage Ⅲ-Ⅳ, low differentiation, and peripheral blood Th17, MLR in the poor prognosis group were higher than those in the good prognosis group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that clinical stage (OR=1.985, 95%CI: 1.167-3.376), Th17 (OR=2.126; 95%CI: 1.310-3.449), MLR(OR=2.353, 95%CI: 1.276-4.337) were independent risk factor affecting the prognosis of colorectal patients (P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of Th17, MLR, and their combined prediction of patient prognosis were 0.732, 0.746, and 0.939, respectively. Conclusion Th17 and MLR in peripheral blood are independent risk factors affecting the prognosis of patients with colorectal cancer, and their combined detection can effectively predict the prognosis of patients. |
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