| 周换丽,石方方,甘田,魏滢,孔艳华.踝肱指数联合血清25-羟维生素D水平对2型糖尿病下肢血管病变的诊断价值[J].中国医药导报,2024,21(6):86-89 |
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| 踝肱指数联合血清25-羟维生素D水平对2型糖尿病下肢血管病变的诊断价值 |
| Diagnostic value of ankle-brachial index combined with serum 25-hydro- xyvitamin D level in lower extremity vascular lesions of type 2 diabetes mellitus |
| 收稿日期： 修订日期：2023-05-06 |
| DOI：10.20047/j.issn1673-7210.2024.06.20 |
| 关键词: 踝肱指数 25羟维生素D 2型糖尿病 下肢血管病变 诊断价值 |
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| 基金项目:安徽省自然科学基金项目（KJ2021A1146） |
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| 摘要:目的 探讨踝肱指数（ABI）联合血清25-羟维生素D[25（OH）D]水平对2型糖尿病下肢血管病变的诊断价值。 方法 选择2018年7月至2021年1月安徽省亳州市人民医院收治的179例2型糖尿病患者，根据是否发生下肢血管病变将其分为未病变组（106例）与病变组（73例）。分析2型糖尿病患者发生下肢血管病变的影响因素，分析ABI联合血清25（OH）D水平对其的诊断价值。 结果 病变组年龄、糖化血红蛋白、低密度脂蛋白胆固醇高于非病变组，白蛋白、ABI、血清25（OH）D水平低于非病变组（P＜0.05）。多因素分析结果显示，年龄（OR= 2.843，95%CI：1.250～6.468）、糖化血红蛋白（OR=3.056，95%CI：1.343～6.951）、ABI（OR=2.724，95%CI：1.197～6.196）、血清25（OH）D水平（OR=3.979，95%CI：1.749～9.051）为2型糖尿病患者发生下肢血管病变的影响因素（P＜0.05）。ABI、血清25（OH）D水平联合预测2型糖尿病下肢血管病变的曲线下面积高于二者单独预测（P＜0.05）。 结论 ABI联合血清25（OH）D水平对2型糖尿病患者发生下肢血管病变具有一定的诊断价值，临床中应予以重视。 |
| Abstract:Objective To investigate the diagnostic value of ankle-brachial index (ABI) combined with serum 25-hydroxy- vitamin D(25[OH]D) level in lower extremity vascular lesions of type 2 diabetes mellitus. Methods A total of 179 patients with type 2 diabetes mellitus admitted to Bozhou People’s Hospital in Anhui Province from July 2018 to January 2021 were selected and divided into non-lesion group (106 cases) and lesion group (73 cases) according to whether they had lower extremity vascular lesions. The influencing factors of lower extremity vascular lesions in patients with type 2 diabetes mellitus and the diagnostic value of ABI-combined with serum 25 (OH) D levels were analyzed. Results The age, glycosylated hemoglobin, and lowdensity lipoprotein-cholesterol in the lesion group were higher than those in the non-lesion group, and the albumin, ABI, and serum 25 (OH) D levels were lower than those in the non-lesion group (P＜0.05). Multivariate analysis showed that age (OR=2.843, 95%CI: 1.250-6.468), glycosylated hemoglobin (OR=3.056, 95%CI: 1.343-6.951), ABI (OR=2.724, 95%CI: 1.197-6.196), and serum 25 (OH) D level (OR=3.979, 95%CI: 1.749-9.051) were the influencing factors of lower extremity vascular lesions in patients with type 2 diabetes mellitus (P＜0.05). The area under the curve of the combination of ABI and serum 25 (OH) D level in predicting lower extremity vascular lesions of type 2 diabetes mellitus was higher than that of ABI and serum 25 (OH) D level alone (P＜0.05). Conclusion ABI combined with serum 25 (OH) D level has a certain diagnostic value for lower extremity vascular lesions in patients with type 2 diabetes mellitus, which should be paid attention to in clinical practice. |
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